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A systematic review assessing the effects of ashwagandha for anxiety and stress response included five randomized controlled human trials. An analysis of results indicated that ashwagandha intervention resulted in greater score improvements than placebo in outcomes shown on anxiety or stress scales, with no observed adverse events.
SHODEN® INDUSTRY-LEADING CONCENTRATION SUPPORTS A MORE RESTFUL NIGHT SLEEP
Shoden® Ashwagandha Extract Shoden is an extract derived from the leaves and roots of the ashwagandha plant. This multi-patented ashwagandha extract is distinguished by its industry-leading concentration of 35% withanolide glycosides. Shoden has been clinically studied for its adaptogenic role in the stress response and for support of a more restful night sleep. Additionally, studies designed specifically to assess the safety of Shoden resulted in no adverse or toxic effects. Company Name’s Ashwagandha Complete contains 240 mg of Shoden per the two-capsule daily dose.
A randomized, double-blind, placebo-controlled trial in adults (N = 60) was designed to assess the stress-balancing effects and the potential mechanism of action of Shoden. Test subjects given 240 mg of Shoden daily for 60 days demonstrated reduced levels of the stress hormone cortisol and the steroidal hormone DHEA-S. There was also an increase of testosterone in male participants. Although other potential mechanisms of action were not investigated, the results of this study suggested ashwagandha has an attenuating effect on the hypothalamic-pituitary-adrenal axis activity in stressed individuals.
Results from a randomized, controlled trial in adult males (N = 57) with moderate fatigue who were given Shoden daily for 16 weeks indicated significant improvements in salivary levels of the steroid hormones DHEA-S and testosterone, which typically decline with age. Additionally, although insignificant, self-reported improvements in fatigue, vigor, and sexual and psychological well-being were documented via questionnaire. No significant difference was recorded for salivary cortisol levels; however, it should be noted that in previous findings serum rather than salivary cortisol was assessed.
To ascertain the effect of Shoden on restorative sleep, healthy subjects (N = 150) were given 120 mg of Shoden daily for 6 weeks in a double-blind, placebo-controlled study. The overall quality of sleep was evaluated using a weekly questionnaire and an assessment of parameters such as sleep latency, sleep efficiency, and total sleep time as measured by a wearable sleep actigraphy diagnostic monitoring device. A significant improvement of sleep measures that define non-restorative sleep were noted in the treatment group when compared to placebo, demonstrating the positive effect of Shoden on encouraging restful sleep
Take one capsule twice daily, or as directed by your healthcare professional.
FORMULATED TO EXCLUDE
Wheat, gluten, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified
organisms (GMOs), artificial colors, artificial sweeteners, and artificial preservatives.
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
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Manhasset, NY 11030
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1. Curcumin’s unique active ingredients have rich medical value
Curcumin in curcuminoids is the focus of discussion here, is the most medically valuable part, accounting for about 3% -5% by weight, although not much, it has a very strong anti-inflammatory Antioxidant ability, the current medical research is to use this ingredient mainly. Curcumin is not easily absorbed by the human body when used alone (the oral absorption rate is only 1% in animal experiments), so thanks to modern technology, there are many absorption-enhancing formulas, such as Meriva is combined with lecithin, other For example, the addition of piperine, phospholipids or the addition of plant-derived essential oil components are said to increase bioavailability several times.
2. Beneficial blood pressure regulation
High blood pressure is a part of a clinical syndrome, its cause is multifaceted, caused by a combination of genetic, environmental and behavioral factors, can lead to the development of the complex cardiovascular disease, it is estimated that people over 60 years of age Among them, 65% are affected by the disease. Data from observational studies show that the risk of coronary artery disease and stroke gradually increases from 115/75 mm Hg and above and for every 20/10 mm Hg increase in blood pressure, the mortality rate of both diseases doubles. A systematic literature review and meta-analysis (including 11 randomized controlled trials, a total of 734 participants) pointed out that, overall, Oral curcumin and turmeric have no obvious effect on reducing systolic blood pressure (SBP) and diastolic blood pressure (DBP). In addition, subgroup analysis showed that in studies supplemented ≥ 12 weeks, systolic blood pressure levels were significantly r
3. Beneficial non-alcoholic fatty liver
Nonalcoholic fatty liver disease is characterized by the accumulation of liver fat greater than 5%, and without any secondary causes, such as excessive drinking, viral hepatitis, Wilson disease, hemochromatosis, autoimmune hepatitis, cholestatic liver disease, hunger, dyslipidemia, celiac disease, Cushing’s disease, and medication (corticosteroids, methotrexate, diltiazem, oxaliplatin, amiodarone, isoniazid, Highly effective antiretroviral therapy, etc.). It is currently estimated that the global prevalence of the non-alcoholic fatty liver disease is as high as 1 billion, including simple steatosis and nonalcoholic steatohepatitis, which can eventually lead to fibrosis and cirrhosis, and may progress to the liver Cirrhosis or hepatocellular carcinoma is the most important cause of cryptogenic cirrhosis. A meta-analysis (including 4 randomized placebo-controlled trials, a total of 229 non-alcoholic fatty liver patients) pointed out that curcumin can effectively reduce low-density lipoprotein cholesterol (LDL-C), triglycerides, fasting blood sugar, insulin resistance (HOMA-IR), weigh and aminotransferase (AST) levels. In addition, related benefits do not significantly help total cholesterol, high-density lipoprotein cholesterol (HDL-C), glycated hemoglobin (HbA1c), alanine aminotransferase (ALT), and insulin.
4. Beneficial submucosal fibrosis
Oral submucous fibrosis is a chronic latent disease affecting the oral cavity, which can involve the throat or esophagus. Due to the mucosal fibrosis, oral mucosa and deep tissue harden, which gradually leads to difficulty in eating, swallowing, and pronunciation. The etiology of this disease is unknown, and it is generally believed that various factors that may cause submucosal fibrosis include: genetic susceptibility, capsaicin, betel nut chewing, autoimmunity, hormones, and lack of nutrition, such as Vitamin B12 and iron. A systematic review (including 6 randomized clinical trials, a total of 298 patients with oral submucosal fibrosis) pointed out that oral curcumin can effectively relieve related symptoms and signs, especially the most obvious pain or burning sensation.
5. Good osteoarthritis
Osteoarthritis is the most common type of arthritis (mainly affecting the joints of the knee, hands, and hips). It is a disabling, late-onset, and degenerative disease characterized by loss of articular cartilage and inflammation of the synovium, leading to joint stiffness, swelling, pain, and loss of mobility. Specifically, the incidence of knee osteoarthritis is mainly related to overweight, obesity, female gender, and previous knee injury. About half of the population over the age of 65 is affected, with women having a higher percentage of menopause than men (18% vs. 9.6%). A systematic literature review and meta-analysis (including 7 randomized controlled trials with a total of 797 participants with primary knee osteoarthritis) pointed out that curcumin-based compounds (day dose ranging from 180 mg to 2 g, intervention time is 4 to 16 weeks) can significantly reduce knee pain and improve the quality of life of patients. In addition, compared with the anti-inflammatory drug ibuprofen, curcumin has lower effects on pain relief, knee stiffness, and body function, but it can significantly reduce the frequency of rescue drugs.
6. Good for diabetes
Type 2 diabetes is a serious and common chronic disease caused by complex genetic-environmental interactions and other risk factors such as obesity and a sedentary lifestyle. In addition, the lack of first-phase insulin release, abnormal pulsatile basal insulin secretion, and increased glucagon secretion will also accelerate the development of type 2 diabetes. A systematic literature review and meta-analysis (including 12 randomized controlled trials, a total of 1154 pre-diabetes and type 2 diabetes participants) pointed out: For prediabetes, curcumin can significantly reduce glycated hemoglobin. In addition, for type 2 diabetes mellitus, curcumin can significantly reduce glycated hemoglobin (HbA1c) and fasting plasma glucose.
7. Improve brain-derived neurotrophic factor
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophic factor family. Others include nerve growth factor, neurotrophic factor 3, and neurotrophic factor 4. Brain-derived neurotrophic factor is one of the neurotrophic factors that support the differentiation, maturation, morphological plasticity, and survival of neurons in the nervous system. It has neuroprotective effects under adverse conditions such as glutamate stimulation, cerebral ischemia, hypoglycemia, and neurotoxicity. Many neurodegenerative and mental diseases, such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, Huntington’s disease, major depression, bipolar disorder, schizophrenia, and anxiety disorders, are associated with low BDNF levels. A systematic literature review and meta-analysis (including 4 randomized controlled trials with a total of 139 participants) indicated that curcumin supplementation (daily doses ranging from 200 mg to 1820 mg, trial duration from 8 to 12 weeks) Can significantly increase serum brain-derived neurotrophic factor (BDNF) levels. In addition, a subgroup analysis showed that the effect of increasing serum BDNF levels was particularly significant in the following subjects, such as women, participants over 40 years old, high-dose curcumin (≥500 mg/d), and longer trials Time (>8 weeks).
8. Beneficial irritability of large intestine (referred to as intestinal irritability)
Irritable bowel syndrome is a chronic functional gastrointestinal disease that affects 9% to 23% of the world’s population. It is typically characterized by repeated abdominal pain and changes in bowel habits (diarrhea, constipation, or both), But no detectable structural and biochemical abnormalities (eg, gastrointestinal bleeding, weight loss, fever, anemia, or abdominal mass). Due to the variable clinical symptoms of colorectal irritability, common comorbidities include gastroesophageal reflux, genitourinary symptoms, fibromyalgia, headache, back pain, and psychological symptoms, so they are often misdiagnosed initially. A systematic literature review and meta-analysis (including 3 randomized controlled trials, a total of 326 patients with irritable bowel syndrome) pointed out that although curcumin improved the symptoms of irritable bowel syndrome, although it was helpful, the effect was not statistically significant (Compared to placebo).
9. Relieve ulcerative colitis
Ulcerative Colitis belongs to a subgroup of intestinal inflammatory diseases. It is a chronic disease affecting the mucosa of the rectum and colon, affecting more than 600,000 Americans. , Immunity disorders, and intestinal bacteria imbalance. Common symptoms include bloody diarrhea, abdominal pain, fever, high fever, weight loss, and diffuse tenderness in the abdomen. The 10-year colonoscopy resection rate is 9% to 24%, and the cumulative 25-year colonoscopy resection rate is 33% to 45%. A systematic literature review and meta-analysis (including 3 randomized controlled trials for patients with mild to moderate ulcerative colitis) pointed out that curcumin adjuvant therapy is more effective for disease remission or clinical improvement compared to placebo The reaction has no obvious effect.
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