• Provides Concentrated Glucoraphanin from Broccoli Seed Extract
• Supports Healthy Cell-Life Cycles
• Supports Phase II Detoxification Enzymes
• Supports Extended Antioxidant Activity
$114.00 USD $145.00 USD You save: 21% ( $31.00 USD )
A systematic review assessing the effects of ashwagandha for anxiety and stress response included five randomized controlled human trials. An analysis of results indicated that ashwagandha intervention resulted in greater score improvements than placebo in outcomes shown on anxiety or stress scales, with no observed adverse events.
SHODEN® INDUSTRY-LEADING CONCENTRATION SUPPORTS A MORE RESTFUL NIGHT SLEEP
Shoden® Ashwagandha Extract Shoden is an extract derived from the leaves and roots of the ashwagandha plant. This multi-patented ashwagandha extract is distinguished by its industry-leading concentration of 35% withanolide glycosides. Shoden has been clinically studied for its adaptogenic role in the stress response and for support of a more restful night sleep. Additionally, studies designed specifically to assess the safety of Shoden resulted in no adverse or toxic effects. Company Name’s Ashwagandha Complete contains 240 mg of Shoden per the two-capsule daily dose.
A randomized, double-blind, placebo-controlled trial in adults (N = 60) was designed to assess the stress-balancing effects and the potential mechanism of action of Shoden. Test subjects given 240 mg of Shoden daily for 60 days demonstrated reduced levels of the stress hormone cortisol and the steroidal hormone DHEA-S. There was also an increase of testosterone in male participants. Although other potential mechanisms of action were not investigated, the results of this study suggested ashwagandha has an attenuating effect on the hypothalamic-pituitary-adrenal axis activity in stressed individuals.
Results from a randomized, controlled trial in adult males (N = 57) with moderate fatigue who were given Shoden daily for 16 weeks indicated significant improvements in salivary levels of the steroid hormones DHEA-S and testosterone, which typically decline with age. Additionally, although insignificant, self-reported improvements in fatigue, vigor, and sexual and psychological well-being were documented via questionnaire. No significant difference was recorded for salivary cortisol levels; however, it should be noted that in previous findings serum rather than salivary cortisol was assessed.
To ascertain the effect of Shoden on restorative sleep, healthy subjects (N = 150) were given 120 mg of Shoden daily for 6 weeks in a double-blind, placebo-controlled study. The overall quality of sleep was evaluated using a weekly questionnaire and an assessment of parameters such as sleep latency, sleep efficiency, and total sleep time as measured by a wearable sleep actigraphy diagnostic monitoring device. A significant improvement of sleep measures that define non-restorative sleep were noted in the treatment group when compared to placebo, demonstrating the positive effect of Shoden on encouraging restful sleep
DIRECTIONS
Take one capsule daily, or as directed by your healthcare professional.
FORMULATED TO EXCLUDE
Wheat, gluten, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified
organisms (GMOs), artificial colors, artificial sweeteners, and artificial preservatives.
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
Distributed By InnerLight Remedies
1410 Northern Blvd #1013
Manhasset, NY 11030
800-520-2530
WHEN WILL MY ORDER SHIP
Orders generally ship within 48 hours of purchase. During times of higher traffic, such as the release of a new product, this time may be extended.
SHIPPING COSTS
Free shipping for US and For International Order Shipping fees vary by product and quantity. Please review your cart before submitting your order for accu-
rate shipping costs.
SHIPPING TIME FRAME
Domestic orders are normally delivered within 5-7 business days from the ship date. International orders are normally delivered within 2-4 weeks from the
ship date. Please keep in mind that this is from ship date, not order date. This also does not include customs processing time for
international orders.
Glucoraphanin
Glucoraphanin (also known as sulforaphane glucosinolate or “sgs”) is a naturally occurring phytochemical found in cruciferous vegetables and in Gastro Health formulas. Glucoraphanin, which is heat stable and water soluble, is metabolized in the body to the biologically active isothiocyanate sulforaphane (SFN). Scientists at Johns Hopkins University School of Medicine isolated sulforaphane in 1992 and identified glucoraphanin as its precursor. Since their discovery, over 500 scientific studies have been conducted on SFN and glucoraphanin, documenting their positive effects on antioxidant activity, detoxification, cellular metabolism, and cell-life regulation. Glucoraphanin and SFN appear to be the “missing link” that correlates a diet rich in cruciferous vegetables (from the Brassicaceae family) with good health. Glucoraphanin from food is enzymatically converted to SFN via the action of the myrosinase enzyme during chewing and food preparation (cutting/ slicing). Gastrointestinal microorganisms are able to produce SFN from glucoraphanin as well. Microorganism conversion is an important contribution to SFN production as the myrosinase enzyme is easily inactivated by heat.Early research identified broccoli sprouts as a concentrated source of glucoraphanin. It is present in much higher concentrations in broccoli seeds and three-day–old broccoli sprouts than in the mature vegetable.One capsule of Gastro Health provides 30 g of glucoraphanin, which equates to approximately 0.33 oz of broccoli sprouts or 8 oz of broccoli.
Antioxidant and Detoxification Support
Sulforaphane, upon conversion from glucoraphanin, is found to be an effective long-acting indirect antioxidant and significant inducer of phase II detoxification enzymes. Research suggests that SFN strongly induces expression of key enzymes (via the KEAP1/Nrf2/ARE pathway), which in turn supports antioxidant activity, redox cycling, and phase II detoxification. The antioxidant enzymes generated are believed to participate in the recycling and maintenance of vitamins A, C, and E as well. After studying the effects of various doses of glucoraphanin administered to study subjects, researchers suggest that there may be a dose-dependent association between glucoraphanin and antioxidant enzyme induction. Accordingly, a metabolically effective dose may vary from tissue to tissue (e.g., upper airway, gastric mucosa, mammary, etc.). Activation of transcription factor Nrf2 induces increased output of specialized enzymes, an output that can extend antioxidant activity 72 hours or more. This is a significantly longer activity phase than direct antioxidants, such as vitamin C, vitamin E, and beta-carotene, are able to promote. Adequate antioxidant protection is crucial to maintaining the health and function of cells, tissues, and organs. Because they assist in maintaining health throughout adult life, phytonutrients, such as glucoraphanin and SFN, are considered “lifespan essentials.”
Support for Cellular Health and Cell-Life Cycles
Glucoraphanin and SFN are believed to play an important role in maintaining healthy gastrointestinal flora; healthy cellular life cycles; immune, eye, and cardiovascular health; and a normal response to inflammation. Sulforaphane’s induction of phase II enzymes, coupled with an inhibitory effect on certain phase I enzymes, is considered to have a protective effect on cells. Research suggests that SFN plays a multidimensional role in maintaining normal cellular life cycles, inhibiting tubulin polymerization, activating checkpoint 2 kinase, and inhibiting histone deacetylase activity. These actions assist in gene regulation, normal cell growth, and cytokine balance. Research suggests that sulforaphane’s effect on Nrf2 pathways, macrophage activation, and NF-kappa B may support a normal, healthy response to inflammation and promote cardiovascular and eye health. Sulforaphane is also studied for its role in maintaining immune health and a healthy gastrointestinal microflora.
We understand you want a good diet, a healthy life-style, and even practice meditation to connect to your innerlight. Our job is to help you on your journey by bringing you quality supplements to heal your body.
We understand you want a good diet, a healthy life-style, and even practice meditation to connect to your innerlight. Our job is to help you on your journey by bringing you quality supplements to heal your body.
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