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A systematic review assessing the effects of ashwagandha for anxiety and stress response included five randomized controlled human trials. An analysis of results indicated that ashwagandha intervention resulted in greater score improvements than placebo in outcomes shown on anxiety or stress scales, with no observed adverse events.
SHODEN® INDUSTRY-LEADING CONCENTRATION SUPPORTS A MORE RESTFUL NIGHT SLEEP
Shoden® Ashwagandha Extract Shoden is an extract derived from the leaves and roots of the ashwagandha plant. This multi-patented ashwagandha extract is distinguished by its industry-leading concentration of 35% withanolide glycosides. Shoden has been clinically studied for its adaptogenic role in the stress response and for support of a more restful night sleep. Additionally, studies designed specifically to assess the safety of Shoden resulted in no adverse or toxic effects. Company Name’s Ashwagandha Complete contains 240 mg of Shoden per the two-capsule daily dose.
A randomized, double-blind, placebo-controlled trial in adults (N = 60) was designed to assess the stress-balancing effects and the potential mechanism of action of Shoden. Test subjects given 240 mg of Shoden daily for 60 days demonstrated reduced levels of the stress hormone cortisol and the steroidal hormone DHEA-S. There was also an increase of testosterone in male participants. Although other potential mechanisms of action were not investigated, the results of this study suggested ashwagandha has an attenuating effect on the hypothalamic-pituitary-adrenal axis activity in stressed individuals.
Results from a randomized, controlled trial in adult males (N = 57) with moderate fatigue who were given Shoden daily for 16 weeks indicated significant improvements in salivary levels of the steroid hormones DHEA-S and testosterone, which typically decline with age. Additionally, although insignificant, self-reported improvements in fatigue, vigor, and sexual and psychological well-being were documented via questionnaire. No significant difference was recorded for salivary cortisol levels; however, it should be noted that in previous findings serum rather than salivary cortisol was assessed.
To ascertain the effect of Shoden on restorative sleep, healthy subjects (N = 150) were given 120 mg of Shoden daily for 6 weeks in a double-blind, placebo-controlled study. The overall quality of sleep was evaluated using a weekly questionnaire and an assessment of parameters such as sleep latency, sleep efficiency, and total sleep time as measured by a wearable sleep actigraphy diagnostic monitoring device. A significant improvement of sleep measures that define non-restorative sleep were noted in the treatment group when compared to placebo, demonstrating the positive effect of Shoden on encouraging restful sleep
Take one to two capsules twice daily at least 30 minutes before or two hours after a meal, or as directed by your healthcare professional.
FORMULATED TO EXCLUDE
Wheat, gluten, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified
organisms (GMOs), artificial colors, artificial sweeteners, and artificial preservatives.
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
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1410 Northern Blvd #1013
Manhasset, NY 11030
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Natto is a fermented, cheese-like food that is popular in Japan where it has been consumed safely for more than 1000 years. It is made through the fermentation of boiled soybeans by the bacterium Bacillus subtilis natto. In 1980, during a series of in vitro experiments at the University of Chicago Medical School, Dr. Hiroyuki Sumi discovered that natto could affect fibrin levels. Fibrin is a whitish, filamentous protein that is formed in blood after a trauma or injury to protect the body from excessive blood loss. Strands of fibrin can accumulate along the walls of blood vessels and affect blood flow. After Dr. Sumi discovered the effect of natto on fibrin, he proceeded to look for natto’s active component. He then isolated and named this component “nattokinase,” which means “enzyme in natto.” According to Dr. Sumi, a 150 g portion of natto contains approximately 500 mg of nattokinase. Nattokinase is produced by Bacillus subtilis natto during the soybean fermentation process. While other soy foods contain enzymes, it is only the natto preparation that contains the nattokinase enzyme. Nattokinase is not a kinase enzyme, it is a serine proteinase class of enzyme.
How Nattokinase Works
Nattokinase supports healthy levels of fibrin and supports healthy blood flow through protease enzyme action (e.g., subtilisin protease, bacillopeptidase F). Not only does nattokinase act directly on fibrin, but as demonstrated by in vitro work, its action also causes the release of substances that trigger the body’s production of other important enzymes that help regulate fibrin formation. Nattokinase can also inhibit a key enzyme that affects extracellular and arterial vasoconstriction, and it can generate tissue plasminogen activators. Other in vitro work revealed that nattokinase caused a significant, dose-dependent decrease of red blood cell aggregation and low-shear viscosity, and these beneficial effects were evident at concentrations similar to those achieved with in vivo animal trials. The Japanese have long believed that natto supports healthy blood flow. Now, as outlined above, modern science has uncovered mechanisms underlying this belief.
Animal and Human Studies
In preliminary research performed by Dr. Sumi and his colleague Masugi Maruyama, extract of natto (equivalent to 25 mg and 200 mg respectively) showed a healthy influence on blood pressure in Wistar rats and in humans. In another animal study performed on dogs, nattokinase was tested against a placebo. Oral administration (1 g nattokinase in four capsules containing 250 mg each) supported normal circulation, as shown by angiogram. More recently, to examine the effects of nattokinase supplementation on blood pressure in humans, 86 people aged 20 to 80 years participated in an eight-week, randomized, double-blind, placebo-controlled trial. Seventy-three subjects completed the protocol. The researchers found that oral nattokinase supplementation (2000 FU/capsule) resulted in a healthy effect on blood flow. InnerLight Remedies’s Vasculo Flow provides 1000 FU/capsule with a recommended dosage of two capsules per day.
It is important to note that both natto and nattokinase have been demonstrated to have activity in humans, whereas supplementing with boiled soybeans did not. Animal research has demonstrated that nattokinase escapes the action of digestive enzymes and is absorbed from the small intestine to perform in plasma.
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