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A systematic review assessing the effects of ashwagandha for anxiety and stress response included five randomized controlled human trials. An analysis of results indicated that ashwagandha intervention resulted in greater score improvements than placebo in outcomes shown on anxiety or stress scales, with no observed adverse events.
SHODEN® INDUSTRY-LEADING CONCENTRATION SUPPORTS A MORE RESTFUL NIGHT SLEEP
Shoden® Ashwagandha Extract Shoden is an extract derived from the leaves and roots of the ashwagandha plant. This multi-patented ashwagandha extract is distinguished by its industry-leading concentration of 35% withanolide glycosides. Shoden has been clinically studied for its adaptogenic role in the stress response and for support of a more restful night sleep. Additionally, studies designed specifically to assess the safety of Shoden resulted in no adverse or toxic effects. Company Name’s Ashwagandha Complete contains 240 mg of Shoden per the two-capsule daily dose.
A randomized, double-blind, placebo-controlled trial in adults (N = 60) was designed to assess the stress-balancing effects and the potential mechanism of action of Shoden. Test subjects given 240 mg of Shoden daily for 60 days demonstrated reduced levels of the stress hormone cortisol and the steroidal hormone DHEA-S. There was also an increase of testosterone in male participants. Although other potential mechanisms of action were not investigated, the results of this study suggested ashwagandha has an attenuating effect on the hypothalamic-pituitary-adrenal axis activity in stressed individuals.
Results from a randomized, controlled trial in adult males (N = 57) with moderate fatigue who were given Shoden daily for 16 weeks indicated significant improvements in salivary levels of the steroid hormones DHEA-S and testosterone, which typically decline with age. Additionally, although insignificant, self-reported improvements in fatigue, vigor, and sexual and psychological well-being were documented via questionnaire. No significant difference was recorded for salivary cortisol levels; however, it should be noted that in previous findings serum rather than salivary cortisol was assessed.
To ascertain the effect of Shoden on restorative sleep, healthy subjects (N = 150) were given 120 mg of Shoden daily for 6 weeks in a double-blind, placebo-controlled study. The overall quality of sleep was evaluated using a weekly questionnaire and an assessment of parameters such as sleep latency, sleep efficiency, and total sleep time as measured by a wearable sleep actigraphy diagnostic monitoring device. A significant improvement of sleep measures that define non-restorative sleep were noted in the treatment group when compared to placebo, demonstrating the positive effect of Shoden on encouraging restful sleep.
Take one to two capsules daily, or as directed by your healthcare professional.
FORMULATED TO EXCLUDE
Wheat, gluten, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified
organisms (GMOs), artificial colors, artificial sweeteners, and artificial preservatives.
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
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1410 Northern Blvd #1013
Manhasset, NY 11030
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Herbs have been used to support health and well-being throughout history and across cultures and are the cornerstone of many ancient medical systems, including Ayurveda and Traditional Chinese Medicine (TCM). Vira Rid comprises three herbs that have been used traditionally and specifically to support the body’s immune system.
Andrographis Extract (Andrographis paniculata)
Andrographis has been used widely in traditional medical systems as a bitter herb that works quickly to support upper respiratory health and immune response. TCM categorizes andrographis as “bitter” and “cold.” The herb has been used to support temperature regulation, respiratory health, immune function, and cytokine and eicosanoid balance. A randomized, double-blind, placebo-controlled study investigated the use of 1200 mg/day (standardized to 4% andrographolides) in 158 adult patients. Results revealed that individuals receiving the herb had a significant improvement in several of the parameters measured when compared to placebo. A “high degree of effectiveness” was observed by day two of treatment.
Research on andrographolide, a major constituent of andrographis, suggests that this bioactive component supports immune activity in human cells by increasing proliferation of lymphocytes, production of interleukin-2, tumor necrosis factor-alpha, and cluster of differentiation (CD) marker expression. A phase I dose-escalating trial of andrographolide was conducted in a select group of individuals. A significant rise in mean CD4(+) lymphocytes was observed in individuals receiving 10 mg/kg andrographolide (p = 0.002). It was noted in the study that prolonged use of concentrated andrographolide may lead to dose-related (5-10 mg/kg) adverse effects for some individuals, a point that should be considered when calculating individual dosing. Acute toxicology studies in rodents noted no observed adverse effects at doses up to 5 g/kg of andrographolide. Researchers did note significant increases in white blood cell and lymphocyte counts as well as a reduction in urea, suggesting that andrographolide had immune-stimulant and renal protective effects. Andrographolide isstandardized to 50% in Vira Rid.
Licorice Root Extract (Glycyrrhiza glabra)
Medicinal use of licorice dates back to ancient Greece, China, India, and Egypt. Contemporary research suggests that its active component glycyrrhizin supports the human immune system in the presence of pathogens. A 2004 study found that glycyrrhizin more effectively supported immune function than other compounds studied (ribavirin, 6-azauridine, pyrazofurin, and mycophenolic acid). Research suggests that mechanisms of action for glycyrrhizin include induction of T-cell interferon-gamma and interference with the pathogen’s membrane. Licorice also appears to play a role in maintaining a healthy mucous membrane (including that of the respiratory tract), stimulating mucus production, and supporting eicosanoid balance in the body. Long-term intake of high doses of glycyrrhizin may deplete potassium and exacerbate hypertension. Although general dosing for standardized glycyrrhizin ranges from 40 to 360 mg per day, and Vira Rid provides approximately 40 mg of standardized glycyrrhizin per two- capsule dose, short-term supplementation with Vira Rid is recommended.
Indigowoad Root Extract (Isatis indigotica)
Indigowoad is commonly used in TCM to support the immune system and upper respiratory tract. A closer look at the mechanism of action for indigowoad root extract in animals revealed that the extract significantly increased spleen weight as well as the number of circulating white blood cells, lymphocytes in particular. The same study found that the indigowoad extract stimulated macrophage phagocytic activity and reduced the suppressive effect that hydrocortisone has on the immune system. A human neutrophil cell study indicated that the isaindigotone derivative of I indigotica was able to scavenge superoxide free radicals and inhibit 5-lipoxygenase and leukotriene B(4) metabolism, ultimately supporting a healthy eicosanoid balance.
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